Grayl's Hotel is ideally situated in downtown St. Petersburg within a 5 minute walk of over 30 restaurants, bars and cafés. Shopping is readily available in the form of boutique shops, galleries and Baywalk. Baywalk also contains a 20 screen movie theatre. Other shops are easily reached by a short drive.

Downtown St. Petersburg is rich with museums and galleries, such as Florida Craftsman Gallery, Museum of History, Florida International Museum, Holocaust Museum, Museum of Fine Arts, and the world famous Salvador Dalí Museum, the only 3 star museum in the South.

Other points of interest in the area are The Pier, The Aquarium, Sunken Gardens, Mahaffey Theatre and the Times Bayfront Arena, USF St. Petersburg Campus, Tropicana Field home of the Tampa Bay Rays, Dolphin Sight-seeing tours, Looper Trolley, Duck Tours of Tampa Bay.

Within a short drive over the bay are The Florida Aquarium, Channelside Mall and IMAX theatres, International Mall, Tampa Bay Performing Arts Center, St. Pete Times Forum- home of the Tampa Bay Lightning and Raymond James Stadium home of the Tampa Bay Buccaneers.